Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction.

doi:10.1073/pnas.92.19.8724

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Article

Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction.

Proceedings of the National Academy of Sciences of the United States of America - 12 Sept 1995

Kawahara A, Minami Y, Miyazaki T, Ihle J N, Taniguchi T

Abstract excerpt

The interleukin 2 receptor (IL-2R) consists of three subunits, the IL-2R alpha, IL-2R beta c, and IL-2R gamma c chains. Two Janus family protein tyrosine kinases (PTKs), Jak1 and Jak3, were shown to associate with IL-2R beta c and IL-2R gamma c, respectively, and their PTK activities are increase...

Topics

Animals
Cell Division
Cell Line
Gene Expression Regulation
Hematopoietic Stem Cells
Humans
Interleukin-2
Janus Kinase 3
Mice
Mutation
Promoter Regions, Genetic
Protein-Tyrosine Kinases
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-fos

Proto-Oncogene Proteins c-myc

Receptors, Interleukin-2

Signal Transduction

Source

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Identifiers

PMID: 7568005
DOI: 10.1073/pnas.92.19.8724
PMCID: PMC41039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7568005-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.