Article
Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ.
Nature communications - 16 Oct 2017
Uehara Mayuko, McGrath Martina M, Ohori Shunsuke, Solhjou Zhabiz, Banouni Naima, Routray Sujit, Evans Catherine, DiNitto Jonathan P, Elkhal Abdallah, Turka Laurence A, Strom Terry B, Tullius Stefan G, Winkler David G, Azzi Jamil, Abdi Reza
Abstract excerpt
Phosphatidylinositol-3-kinases (PI3K) γ and δ are preferentially enriched in leukocytes, and defects in these signaling pathways have been shown to impair T cell activation. The effects of PI3Kγ and PI3Kδ on alloimmunity remain underexplored. Here, we show that both PI3Kγ -/- and PI3Kδ D910A/D910A mice receiving heart allografts have suppression of alloreactive T effector cells and delayed acute rejection....
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