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Article

Suppression of inflammatory responses during myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis is regulated by AKT3 signaling.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2013

Tsiperson Vladislav, Gruber Ross C, Goldberg Michael F, Jordan Ayana, Weinger Jason G, Macian Fernando, Shafit-Zagardo Bridget

Abstract excerpt

AKT3, a member of the serine/threonine kinase AKT family, is involved in a variety of biologic processes. AKT3 is expressed in immune cells and is the major AKT isoform in the CNS representing 30% of the total AKT expressed in spinal cord, and 50% in the brain. Myelin-oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE) is a mouse model in which lymphocytes and monocytes enter the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23335751
DOI: 10.4049/jimmunol.1201387
PMCID: PMC3564598

Genes

AKT3

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