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Article

GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells

9 Feb 2004

Abstract excerpt

T helper type 2 (Th2) cells secrete IL-4, IL-5, IL-10, and IL-13 and mediate allergic and asthmatic disease. GATA-3 is a Th2-specific transcription factor that appears in overexpression studies and transgenic systems to function as a Th2 lineage determinant. Because GATA-3 is also crucial for development of the T lineage and throughout thymic development, direct demonstration that GATA-3 is required for Th2...

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PMID: 14769923
DOI: 10.1073/pnas.0308697100

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