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Article

PKCα and PKCβ cooperate functionally in CD3-induced de novo IL-2 mRNA transcription.

Immunology letters - 1 Mar 2013

Lutz-Nicoladoni Christina, Christina Lutz-Nicoladoni, Thuille Nikolaus, Nikolaus Thuille, Wachowicz Katarzyna, Katarzyna Wachowicz, Gruber Thomas, Thomas Gruber, Leitges Michael, Michael Leitges, Baier Gottfried, Gottfried Baier

Abstract excerpt

The physiological functions of PKCα and PKCθ isotypes downstream of the antigen receptor have been defined in CD3(+) T cells. In contrast, no function of the second conventional PKC member, PKCβ, has been described yet in T cell antigen receptor signalling. To investigate the hypothesis that both conventional PKCα and PKCβ isotypes may have overlapping functions in T cell activation signalling, we generated mice...

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Identifiers

PMID: 23439007
DOI: 10.1016/j.imlet.2013.02.002
PMCID: PMC3641392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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