Article
Dynamics of telomeric DNA turnover in yeast.
Genetics - 1 Jan 2002
McEachern Michael J, Underwood Dana Hager, Blackburn Elizabeth H
Abstract excerpt
Telomerase adds telomeric DNA repeats to telomeric termini using a sequence within its RNA subunit as a template. We characterized two mutations in the Kluyveromyces lactis telomerase RNA gene (TER1) template. Each initially produced normally regulated telomeres. One mutation, ter1-AA, had a cryptic defect in length regulation that was apparent only if the mutant gene was transformed into a TER1 deletion strain...
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