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Article

Microsatellite instability in oral cancer.

International journal of cancer - 20 Oct 1995

Ishwad C S, Ferrell R E, Rossie K M, Appel B N, Johnson J T, Myers E N, Law J C, Srivastava S, Gollin S M

Abstract excerpt

Generalized genomic instability, detected as somatic changes in allele sizes at microsatellite loci in tumors compared to peripheral lymphocyte DNA, is a recently recognized mechanism of mutation in cancer. Such instability results from the somatic loss of DNA mismatch repair capability. Germ-line mutations at DNA mismatch repair loci confer susceptibility to colon cancer in hereditary non-polyposis colorectal...

Topics

Adult
Aged
Alleles
Carcinoma, Squamous Cell
Chromosomes, Human
DNA Repair
DNA Replication
DNA, Neoplasm
DNA, Satellite
Genetic Markers
Humans
Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mouth Neoplasms

Source

Identifiers

PMID: 7591306
DOI: 10.1002/ijc.2910640509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7591306-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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