Article
Microsatellite instability in oral cancer.
International journal of cancer - 20 Oct 1995
Ishwad C S, Ferrell R E, Rossie K M, Appel B N, Johnson J T, Myers E N, Law J C, Srivastava S, Gollin S M
Abstract excerpt
Generalized genomic instability, detected as somatic changes in allele sizes at microsatellite loci in tumors compared to peripheral lymphocyte DNA, is a recently recognized mechanism of mutation in cancer. Such instability results from the somatic loss of DNA mismatch repair capability. Germ-line mutations at DNA mismatch repair loci confer susceptibility to colon cancer in hereditary non-polyposis colorectal...
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