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A dual-fluorescent reporter facilitates identification of thiol compounds that suppress microsatellite instability induced by oxidative stress.

Free radical biology & medicine - 1 Apr 2014

Li I-Chen, Chiu Chien-Yuan, Wu Chang-Lin, Chi Jhih-Ying, Jian Siao-Ru, Wang Shainn-Wei, Chang Christina L

Abstract excerpt

The DNA mismatch-repair (MMR) system corrects replicative errors and minimizes mutations that occur at a high rate in microsatellites. Patients with chronic inflammation or inflammation-associated cancer display microsatellite instability (MSI), indicating a possible MMR inactivation. In fact, H2O2-generated oxidative stress inactivates the MMR function and increases mutation accumulation in a reporter...

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PMID: 24412704
DOI: 10.1016/j.freeradbiomed.2013.12.019

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