Article
Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation.
Nature genetics - 1 Mar 1994
Shibata D, Peinado M A, Ionov Y, Malkhosyan S, Perucho M
Abstract excerpt
Genomic instability at simple repeated sequences (SRS) is a landmark for some sporadic and hereditary cancers of the colon. We have identified several human tumour cell lines with up to 1,000-fold increases in mutation rates for endogenous microsatellite sequences, relative to normal cells or tumour cells without the mutator phenotype and show that they are very early events in tumorigenesis. Our in vivo and in...
Topics
- Cell Transformation, Neoplastic
- Colorectal Neoplasms
- DNA, Neoplasm
- DNA, Satellite
- Female
- Humans
- Male
- Mutation
- Oligodeoxyribonucleotides
- Phenotype
- Repetitive Sequences, Nucleic Acid