Selection for genome instability by DNA damage in human cells: unstable microsatellites and their consequences for tumourigenesis.

doi:10.1002/(SICI)1520-6823(1997)5:3<111::AID-ROI5>3.0.CO;2-0

Article

Selection for genome instability by DNA damage in human cells: unstable microsatellites and their consequences for tumourigenesis.

Radiation oncology investigations - 1 Jan 1997

Hampson R

Abstract excerpt

The emergence of tumour cells resistant to chemotherapeutic treatment is a major confounding factor in anticancer treatment. Many chemotherapeutic drugs are DNA damaging agents. Resistance to DNA damage can be acquired via a plethora of different mechanisms, including, surprisingly, loss of DNA mismatch repair activity. The DNA mismatch repair system acts after DNA replication and corrects non-Watson-Crick base...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Selection for genome instability by DNA damage in human cells: unstable microsatellites and their consequences for tumourigenesis.

Abstract excerpt

Topics

Related research