Selection for genome instability by DNA damage in human cells: unstable microsatellites and their consequences for tumourigenesis.

doi:10.1002/(SICI)1520-6823(1997)5:3<111::AID-ROI5>3.0.CO;2-0

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Article

Selection for genome instability by DNA damage in human cells: unstable microsatellites and their consequences for tumourigenesis.

Radiation oncology investigations - 1 Jan 1997

Hampson R

Abstract excerpt

The emergence of tumour cells resistant to chemotherapeutic treatment is a major confounding factor in anticancer treatment. Many chemotherapeutic drugs are DNA damaging agents. Resistance to DNA damage can be acquired via a plethora of different mechanisms, including, surprisingly, loss of DNA m...

Topics

Antineoplastic Agents
Base Composition
Base Sequence
Chromosome Aberrations
DNA Damage
DNA Repair
DNA Replication
Drug Resistance, Neoplasm
Frameshift Mutation
Genes, Tumor Suppressor
Genome, Human
Humans
Microsatellite Repeats
Mutation
Neoplasms
Phenotype
Repetitive Sequences, Nucleic Acid
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 9303066
DOI: 10.1002/(SICI)1520-6823(1997)5:3<111::AID-ROI5>3.0.CO;2-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9303066-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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