Article
The mutation frequency of 8-oxo-7,8-dihydroguanine (8-oxodG) situated in a multiply damaged site: comparison of a single and two closely opposed 8-oxodG in Escherichia coli.
DNA repair - 11 Jun 2003
Malyarchuk Svitlana, Youngblood Reneau, Landry April M, Quillin Elizabeth, Harrison Lynn
Abstract excerpt
A multiply damaged site (MDS) is defined as > or =2 lesions within a distance of 10-15 base pairs (bp). MDS generated by ionizing radiation contain oxidative base damage, and in vitro studies have indicated that if the base damage is <3bp apart, repair of one lesion is inhibited until repair of the lesion in the opposite strand is completed. Inhibition of repair could result in an increase in the mutation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.