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Article

Different modulation of Ptpn22 in effector and regulatory T cells leads to attenuation of autoimmune diabetes in transgenic nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2013

Yeh Li-Tzu, Miaw Shi-Chuen, Lin Ming-Hong, Chou Feng-Cheng, Shieh Shing-Jia, Chuang Yi-Ping, Lin Shih-Hua, Chang Deh-Ming, Sytwu Huey-Kang

Abstract excerpt

Ptpn22 encodes PEST domain-enriched tyrosine phosphatase (Pep), which negatively regulates TCR proximal signaling and is strongly associated with a variety of autoimmune diseases in humans. The net effect of Pep on the balance of immunity and tolerance is uncertain because of the simultaneous inhibition of TCR-mediated signaling of effector and regulatory T cells (T(regs)). In this study, we generated transgenic...

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PMID: 23752610
DOI: 10.4049/jimmunol.1203380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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