Different modulation of Ptpn22 in effector and regulatory T cells leads to attenuation of autoimmune diabetes in transgenic nonobese diabetic mice.

doi:10.4049/jimmunol.1203380

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Article

Different modulation of Ptpn22 in effector and regulatory T cells leads to attenuation of autoimmune diabetes in transgenic nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2013

Yeh Li-Tzu, Miaw Shi-Chuen, Lin Ming-Hong, Chou Feng-Cheng, Shieh Shing-Jia, Chuang Yi-Ping, Lin Shih-Hua, Chang Deh-Ming, Sytwu Huey-Kang

Abstract excerpt

Ptpn22 encodes PEST domain-enriched tyrosine phosphatase (Pep), which negatively regulates TCR proximal signaling and is strongly associated with a variety of autoimmune diseases in humans. The net effect of Pep on the balance of immunity and tolerance is uncertain because of the simultaneous inhibition of TCR-mediated signaling of effector and regulatory T cells (T(regs)). In this study, we generated transgenic...

Topics

Animals
CD4 Antigens
CD8 Antigens
Cell Differentiation
Cell Proliferation
Cells, Cultured
Diabetes Mellitus, Type 1
Female
Forkhead Transcription Factors
Genotype
Incidence
Interferon-gamma
Male

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred NOD

Mice, Transgenic

Protein Tyrosine Phosphatase, Non-Receptor Type 22

Receptors, Antigen, T-Cell

Source

Open in PubMed

Identifiers

PMID: 23752610
DOI: 10.4049/jimmunol.1203380

Provenance

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