Article
Human and murine T-cell responses to allelic forms of a malaria circumsporozoite protein epitope support a polyvalent vaccine strategy.
Immunology - 1 Jul 1998
Zevering Y, Khamboonruang C, Good M F
Abstract excerpt
Mouse models and a recent vaccine trial have indicated the importance of T-cell immunity to the circumsporozoite protein (CSP) of malaria sporozoites. One of the major impediments for the development of a CSP-based vaccine is that human T-cell epitopes, identified on the CSP, span regions of significant point mutational polymorphism. Studies with human and mouse T-cell clones have indicated that this polymorphism...
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