Human and murine T-cell responses to allelic forms of a malaria circumsporozoite protein epitope support a polyvalent vaccine strategy.

doi:10.1046/j.1365-2567.1998.00514.x

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Article

Human and murine T-cell responses to allelic forms of a malaria circumsporozoite protein epitope support a polyvalent vaccine strategy.

Immunology - 1 Jul 1998

Zevering Y, Khamboonruang C, Good M F

Abstract excerpt

Mouse models and a recent vaccine trial have indicated the importance of T-cell immunity to the circumsporozoite protein (CSP) of malaria sporozoites. One of the major impediments for the development of a CSP-based vaccine is that human T-cell epitopes, identified on the CSP, span regions of sign...

Topics

Alleles
Animals
Antigens, Protozoan
Cell Line
Cross Reactions
Epitopes, T-Lymphocyte
Humans
Malaria
Mice
Mice, Inbred Strains
Plasmodium falciparum
Polymorphism, Genetic
Protozoan Proteins
Protozoan Vaccines
T-Lymphocytes

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