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Plasmodium vivaxPromiscuous T-Helper Epitopes Defined and Evaluated as Linear Peptide Chimera Immunogens

1 Jul 2002

Abstract excerpt

Clinical trials of malaria vaccines have confirmed that parasite-derived T-cell epitopes are required to elicit consistent and long-lasting immune responses. We report here the identification and functional characterization of six T-cell epitopes that are present in the merozoite surface protein-1 of Plasmodium vivax (PvMSP-1) and bind promiscuously to four different HLA-DRB1* alleles. Each of these peptides...

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PMID: 12065487
DOI: 10.1128/iai.70.7.3479-3492.2002

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