Article
Gyramides prevent bacterial growth by inhibiting DNA gyrase and altering chromosome topology.
ACS chemical biology - 20 Jun 2014
Rajendram Manohary, Hurley Katherine A, Foss Marie H, Thornton Kelsey M, Moore Jared T, Shaw Jared T, Weibel Douglas B
Abstract excerpt
Antibiotics targeting DNA gyrase have been a clinical success story for the past half-century, and the emergence of bacterial resistance has fueled the search for new gyrase inhibitors. In this paper we demonstrate that a new class of gyrase inhibitors, the gyramides, are bacteriostatic agents that competitively inhibit the ATPase activity of Escherichia coli gyrase and produce supercoiled DNA in vivo. E. coli...
Topics
- Adenosine Triphosphatases
- Adenosine Triphosphate
- Anti-Bacterial Agents
- Chromosomes, Bacterial
- DNA Gyrase
- DNA Replication
- DNA, Bacterial
- Drug Resistance, Bacterial
- Escherichia coli
- Flow Cytometry
- Molecular Structure
- Mutation
- Pyrrolidines