Article
Mechanism of action of and resistance to quinolones.
Pharmacotherapy - 1 Oct 2001
Bearden D T, Danziger L H
Abstract excerpt
A topoisomerase was identified as the bacterial target site for quinolone action in the late 1970s. Since that time, further study identified two bacterial topoisomerases, DNA gyrase and topoisomerase IV, as sites of antibacterial activity DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms, but this...
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