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Article

Topoisomerase IV, not gyrase, decatenates products of site-specific recombination in Escherichia coli.

Genes & development - 1 Oct 1997

Zechiedrich E L, Khodursky A B, Cozzarelli N R

Abstract excerpt

DNA replication and recombination generate intertwined DNA intermediates that must be decatenated for chromosome segregation to occur. We showed recently that topoisomerase IV (topo IV) is the only important decatenase of DNA replication intermediates in bacteria. Earlier results, however, indicated that DNA gyrase has the primary role in unlinking the catenated products of site-specific recombination. To address...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 9334322
DOI: 10.1101/gad.11.19.2580
PMCID: PMC316566

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Source receipt: pubmed, retrieved 7 Sept 2026.

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