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Article

Lethal fragmentation of bacterial chromosomes mediated by DNA gyrase and quinolones.

Molecular microbiology - 1 Aug 2006

Malik Muhammad, Zhao Xilin, Drlica Karl

Abstract excerpt

When DNA gyrase is trapped on bacterial chromosomes by quinolone antibacterials, reversible complexes form that contain DNA ends constrained by protein. Two subsequent processes lead to rapid cell death. One requires ongoing protein synthesis; the other does not. The prototype quinolone, nalidixi...

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Source

Identifiers

PMID: 16803589
DOI: 10.1111/j.1365-2958.2006.05275.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16803589-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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