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Article

Lethal fragmentation of bacterial chromosomes mediated by DNA gyrase and quinolones.

Molecular microbiology - 1 Aug 2006

Malik Muhammad, Zhao Xilin, Drlica Karl

Abstract excerpt

When DNA gyrase is trapped on bacterial chromosomes by quinolone antibacterials, reversible complexes form that contain DNA ends constrained by protein. Two subsequent processes lead to rapid cell death. One requires ongoing protein synthesis; the other does not. The prototype quinolone, nalidixic acid, kills wild-type Escherichia coli only by the first pathway; fluoroquinolones kill by both. Both lethal...

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Identifiers

PMID: 16803589
DOI: 10.1111/j.1365-2958.2006.05275.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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