Article
The human neonatal B cell response to respiratory syncytial virus uses a biased antibody variable gene repertoire that lacks somatic mutations.
Molecular immunology - 1 Dec 2009
Williams John V, Weitkamp Jörn-Hendrik, Blum David L, LaFleur Bonnie J, Crowe James E
Abstract excerpt
The human Ab repertoire exhibits restrictions during fetal life characterized by biases of variable gene segment usage and lack of junctional diversity. We tested the hypotheses that Ab repertoire restriction persists in the early postnatal period and contributes to the observed poor quality of specific Ab responses made by neonates to viruses and vaccines. We analyzed the molecular determinants of B cell...
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