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Article

Impact of age on hypermutation of immunoglobulin variable genes in humans.

Journal of clinical immunology - 1 Mar 2001

Rosner K, Winter D B, Kasmer C, Skovgaard G L, Tarone R E, Bohr V A, Gearhart P J

Abstract excerpt

Chronological aging is associated with an accumulation of DNA mutations that results in cancer formation. The effect of aging on spontaneous mutations in humans is difficult to study because mutations are infrequent in the overall genome and tumors are relatively rare. In contrast, somatic mutations in immunoglobulin variable genes are abundant and can be studied in peripheral blood lymphocytes. To determine if...

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Source

Identifiers

PMID: 11332649
DOI: 10.1023/a:1011003821798

Genes

PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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