Article
Epitopes of human chorionic gonadotropin and their relationship to immunogenicity and cross-reactivity of beta-chain mutants.
American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Sept 1998
Porakishvili N, Jackson A M, de Souza J B, Dalla Chiesa M, Roitt I M, Delves P J, Lund T
Abstract excerpt
PROBLEM: Human chrionic gonadotropin (hCG) is a placental glycoprotein hormone, a heterodimeric molecule, consisting of alpha and beta chains. It induces the synthesis of progesterone, which is essential for the maintenance of the fertilized egg. Antibodies directed against hCG can, therefore, prevent pregnancy and serve as a vaccine. hCG belongs to the glycoprotein hormone family and shares the alpha chain with...
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