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Article

Human chorionic gonadotropin with C-elongated alpha-subunit retains full receptor binding and partial agonist activity.

European journal of endocrinology - 1 Apr 2000

Marichatou H, Martinat N, Guillou F, Combarnous Y

Abstract excerpt

OBJECTIVE: To test whether extension of the C-terminus of human chorionic gonadotropin (hCG) alpha-subunit (halpha) alters the bioactivity of the recombined alphabeta heterodimer. DESIGN: The stop codon of halpha was mutated to produce a 24 amino acid extension. METHODS: The extended halpha (alpha(+24)) was co-expressed with hCGbeta in COS-7 cells and the receptor binding and in vivo bioactivity of the secreted...

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Identifiers

PMID: 10754483
DOI: 10.1530/eje.0.1420402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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