Article
Antigenic alteration of an anomalous human luteinizing hormone caused by two chorionic gonadotropin-type amino-acid substitutions.
Biochemical and biophysical research communications - 15 Apr 1994
Okuda K, Yamada T, Imoto H, Komatsubara H, Sugimoto O
Abstract excerpt
We analyzed the nucleotide sequence of the luteinizing hormone beta subunit (LH beta) in a patient with an anomalous LH. This anomalous LH showed abnormal immunogenicity, but normal bioactivity, suggesting that this variance of antigenicity was caused by amino acid substitution(s). In the anomalo...
Topics
- Abortion, Habitual
- Adult
- Aged
- Amino Acid Sequence
- Antigens
- Base Sequence
- Chorionic Gonadotropin
- Cloning, Molecular
- DNA
- DNA Primers
- Female
- Genetic Variation
- Heterozygote
- Homozygote
- Humans
- Leukocytes
- Luteinizing Hormone
- Male