Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The major hormone-specific discontinuous epitopes on human chorionic gonadotrophin.

Journal of molecular endocrinology - 1 Apr 2004

Charrel-Dennis M, Jackson A M, Lund T, Lapthorn A J, Berger P, Roitt I M, Delves P J

Abstract excerpt

The hormone human chorionic gonadotrophin (hCG) shows extensive sequence homology with LH. Thus, many of the antigenic epitopes on hCG are shared with LH, leading to immunological cross-reaction between these two hormones. Anti-fertility and anti-cancer vaccines based upon hCG should ideally target only the hCG-specific epitopes. The hCG-unique linear epitopes located in the C-terminal peptide of the hCG...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Carbohydrate Metabolism

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CHO Cells

Share to Cricetinae

Share to Cricetulus

Share to Epitopes

Share to Glycosylation

Share to Hormones

Source

Identifiers

PMID: 15072560
DOI: 10.1677/jme.0.0320571

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The major hormone-specific discontinuous epitopes on human chorionic gonadotrophin.PMID 15072560Read ↗

Epitopes of human chorionic gonadotropin and their relationship to immunogenicity and cross-reactivity of beta-chain mutants.Semantic proximity Read ↗

The human chorionic gonadotropin-beta arginine68 to glutamic acid substitution fixes the conformation of the C-terminal peptide.Semantic proximity Read ↗

Homologous and heterologous carboxyl terminal peptide (CTP) linker sequences enhance the secretion of bioactive single-chain bovine LH analogs.Semantic proximity Read ↗

Single chain human chorionic gonadotropin, hCGalphabeta: effects of mutations in the alpha subunit on structure and bioactivity.Semantic proximity Read ↗

Human chorionic gonadotropin as a target for cancer vaccines.Semantic proximity Read ↗

Human chorionic gonadotropin and associated molecules.Semantic proximity Read ↗

Localization of residues that confer antibody binding specificity using human chorionic gonadotropin/luteinizing hormone beta subunit chimeras and mutants.Semantic proximity Read ↗

Antigenic alteration of an anomalous human luteinizing hormone caused by two chorionic gonadotropin-type amino-acid substitutions.Semantic proximity Read ↗

Functional reconstruction and synthetic mimicry of a conformational epitope using CLIPS technology.Semantic proximity Read ↗

Evaluation of in vivo bioactivities of recombinant hypo- (FSH 21/18 ) and fully- (FSH 24 ) glycosylated human FSH glycoforms in Fshb null miceSemantic proximity Read ↗

Designing a new generation of anti-hCG vaccines for cancer therapy.Semantic proximity Read ↗

The classification, functions and clinical use of different isoforms of HCGSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.