Article
Vernier zone residue 4 of mouse subgroup II kappa light chains is a critical determinant for antigen recognition.
Immunotechnology : an international journal of immunological engineering - 1 Mar 1999
de Haard H, Kazemier B, van der Bent A, Oudshoorn P, Boender P, Arends J W, van Gemen B
Abstract excerpt
BACKGROUND: During the conversion of murine monoclonal antibodies directed against the human chorionic gonadotropin (hCG) into bacterially expressed single chain fragments (scFv), we found a major reduction of binding activity upon introduction of a primer encoded mutation. OBJECTIVES: In this study we tried to determine which mutation was responsible and on what manner this mutation affected antigen binding...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.