Article
On the role of the invariant glutamine at position 54 in the human choriogonadotropin beta subunit.
Molecular and cellular biochemistry - 27 Jul 1994
Huang J, Puett D
Abstract excerpt
The twelve Cys and eight of the non-Cys residues are invariant in the glycoprotein hormone beta subunits from a variety of mammalian species. beta-Gin-54 of human lutropin (hLH) and choriogonadotropin (hCG) is one of these invariant amino acid residues. A single A-->G mutation in the LH beta gene...
Topics
- Animals
- CHO Cells
- Chorionic Gonadotropin
- Chorionic Gonadotropin, beta Subunit, Human
- Cricetinae
- Genetic Variation
- Glutamine
- Lysine
- Mutagenesis, Site-Directed
- Peptide Fragments
- Structure-Activity Relationship