Article
Mutations in CDC14 result in high sensitivity to cyclin gene dosage in Saccharomyces cerevisiae.
Molecular & general genetics : MGG - 1 Feb 2000
Yuste-Rojas M, Cross F R
Abstract excerpt
We screened for mutations that resulted in lethality when the G1 cyclin Cln2p was overexpressed throughout the cell cycle in Saccharomyces cerevisiae. Mutations in five complementation groups were found to give this phenotype, and three of the mutated genes were identified as MEC1, NUP170, and CDC14. Mutations in CDC14 may have been recovered in the screen because Cdc14p may reduce the cyclin B (Clb)-associated...
Topics
- CDC28 Protein Kinase, S cerevisiae
- Cell Cycle
- Cell Cycle Proteins
- Cloning, Molecular
- Cyclins
- DNA Replication
- Fungal Proteins
- Gene Dosage
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Mitosis