Quantitation of mixed-base populations of HIV-1 variants by automated DNA sequencing with BODIPY dye-labeled primers.

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Article

Quantitation of mixed-base populations of HIV-1 variants by automated DNA sequencing with BODIPY dye-labeled primers.

BioTechniques - 1 Sept 1998

Metzker M L, Ansari-Lari M A, Liu X M, Holder D J, Gibbs R A

Abstract excerpt

Direct DNA sequencing of human immunodeficiency virus type 1 (HIV-1) pol and env gene regions was characterized for accuracy and precision. Restricted maximum likelihood (REML) analysis of molecular clone reconstruction experiments using a primer-walking strategy showed that the BODIPY and BODIPY...

Topics

Boron Compounds
DNA Primers
DNA, Viral
DNA-Directed DNA Polymerase
Genes, env
Genes, pol
Genetic Heterogeneity
Genetic Variation
Genome, Viral
HIV Envelope Protein gp120
HIV-1
Humans
Reproducibility of Results
Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 9762443

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9762443-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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