Expedited quantification of mutant ribosomal RNA by binary deoxyribozyme (BiDz) sensors.

doi:10.1261/rna.052613.115

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Article

Expedited quantification of mutant ribosomal RNA by binary deoxyribozyme (BiDz) sensors.

RNA (New York, N.Y.) - 1 Oct 2015

Gerasimova Yulia V, Yakovchuk Petro, Dedkova Larisa M, Hecht Sidney M, Kolpashchikov Dmitry M

Abstract excerpt

Mutations in ribosomal RNA (rRNA) have traditionally been detected by the primer extension assay, which is a tedious and multistage procedure. Here, we describe a simple and straightforward fluorescence assay based on binary deoxyribozyme (BiDz) sensors. The assay uses two short DNA oligonucleotides that hybridize specifically to adjacent fragments of rRNA, one of which contains a mutation site. This...

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Identifiers

PMID: 26289345
DOI: 10.1261/rna.052613.115
PMCID: PMC4574759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.