Article
Targeted resequencing of HIV variants by microarray thermodynamics.
Nucleic acids research - 1 Oct 2013
Hadiwikarta Wahyu W, Van Dorst Bieke, Hollanders Karen, Stuyver Lieven, Carlon Enrico, Hooyberghs Jef
Abstract excerpt
Within a single infected individual, a virus population can have a high genomic variability. In the case of HIV, several mutations can be present even in a small genomic window of 20-30 nucleotides. For diagnostics purposes, it is often needed to resequence genomic subsets where crucial mutations are known to occur. In this article, we address this issue using DNA microarrays and inputs from hybridization...
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