Article
The -491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism.
Neuroscience letters - 14 Aug 1998
Town T, Paris D, Fallin D, Duara R, Barker W, Gold M, Crawford F, Mullan M
Abstract excerpt
The epsilon4 allele of the apolipoprotein E gene (APOE) has repeatedly been associated with increased risk for Alzheimer's disease (AD). Bullido and colleagues recently identified a polymorphism in the promoter region of the APOE gene (-491A/T) and found that -491A homozygosity predicted AD indep...
Topics
- Aged
- Alleles
- Alzheimer Disease
- Apolipoproteins E
- Female
- Gene Frequency
- Genetic Linkage
- Haplotypes
- Humans
- Logistic Models
- Male
- Middle Aged
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Risk Factors