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Article

Degeneration of the amygdala/piriform cortex and enhanced fear/anxiety behaviors in sodium pump alpha2 subunit (Atp1a2)-deficient mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jun 2003

Ikeda Keiko, Onaka Tatsushi, Yamakado Makoto, Nakai Junichi, Ishikawa Tomo-o, Taketo Makoto M, Kawakami Kiyoshi

Abstract excerpt

The sodium pump is the enzyme responsible for the maintenance of Na+ and K+ gradients across the cell membrane. Four isoforms of the catalytic alpha subunit have been identified, but their individual roles remain essentially unknown. To investigate the necessary functions of the alpha2 subunit in vivo, we generated and analyzed mice defective in the alpha2 subunit gene. Mice homozygous for the alpha2 mutation...

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Identifiers

PMID: 12805306
PMCID: PMC6740785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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