Article
Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2.
Physiology & behavior - 15 Apr 2006
Deacon R M J, Brook R C, Meyer D, Haeckel O, Ashcroft F M, Miki T, Seino S, Liss B
Abstract excerpt
ATP-sensitive potassium (K(ATP)) channels are expressed in various tissues and cell-types where they act as so-called metabolic sensors that couple metabolic state to cellular excitability. The pore of most K(ATP) channel types is built by Kir6.2 subunits. Analysis of a general Kir6.2 knockout (KO) mouse has identified a variety of different functional roles for central and peripheral K(ATP) channels in...
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