Article
Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2.
Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 1997
Signorini S, Liao Y J, Duncan S A, Jan L Y, Stoffel M
Abstract excerpt
G protein-gated, inwardly rectifying K+ channels (GIRK) are effectors of G protein-coupled receptors for neurotransmitters and hormones and may play an important role in the regulation of neuronal excitability. GIRK channels may be important in neurodevelopment, as suggested by the recent finding...
Topics
- Animals
- Brain Chemistry
- Cerebellum
- G Protein-Coupled Inwardly-Rectifying Potassium Channels
- GABA Antagonists
- GTP-Binding Proteins
- Gene Dosage
- Genotype
- Male
- Mice
- Mice, Knockout
- Mice, Neurologic Mutants
- Pentylenetetrazole
- Phenotype
- Point Mutation