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Article

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit.

Nature - 12 Jan 1995

Sakimura K, Kutsuwada T, Ito I, Manabe T, Takayama C, Kushiya E, Yagi T, Aizawa S, Inoue Y, Sugiyama H

Abstract excerpt

The NMDA (N-methyl-D-aspartate) receptor channel is important for synaptic plasticity, which is thought to underlie learning, memory and development. The NMDA receptor channel is formed by at least two members of the glutamate receptor (GluR) channel subunit families, the GluR epsilon (NR2) and GluR zeta (NR1) subunit families. The four epsilon subunits are distinct in distribution, properties and regulation. On...

Topics

Animals
Cells, Cultured
Gene Targeting
Hippocampus
Long-Term Potentiation
Maze Learning
Mice
Mice, Inbred Strains
Mutation
Patch-Clamp Techniques
Pyramidal Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Messenger

Receptors, N-Methyl-D-Aspartate

Synapses

Source

Identifiers

PMID: 7816096
DOI: 10.1038/373151a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7816096-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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