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Article

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit.

Nature - 12 Jan 1995

Sakimura K, Kutsuwada T, Ito I, Manabe T, Takayama C, Kushiya E, Yagi T, Aizawa S, Inoue Y, Sugiyama H

Abstract excerpt

The NMDA (N-methyl-D-aspartate) receptor channel is important for synaptic plasticity, which is thought to underlie learning, memory and development. The NMDA receptor channel is formed by at least two members of the glutamate receptor (GluR) channel subunit families, the GluR epsilon (NR2) and GluR zeta (NR1) subunit families. The four epsilon subunits are distinct in distribution, properties and regulation. On...

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Identifiers

PMID: 7816096
DOI: 10.1038/373151a0

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