Strand asymmetry of CpG transitions as indicator of G1 phase-dependent origin of multiple tumorigenic p53 mutations in stem cells.

doi:10.1073/pnas.95.20.11927

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Article

Strand asymmetry of CpG transitions as indicator of G1 phase-dependent origin of multiple tumorigenic p53 mutations in stem cells.

Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 1998

Rodin S N, Rodin A S

Abstract excerpt

In dividing cells, expression of mutations is DNA strand symmetric. Of all mutations originating de novo in nondividing cells, only those in the transcribed (noncoding) strand are immediately expressed in mRNA and protein. In contrast, any new mutation in the nontranscribed (coding) strand remain...

Topics

Animals
Base Sequence
CpG Islands
DNA, Neoplasm
G1 Phase
Genes, p53
Humans
Mice
Models, Genetic
Mutation
Neoplastic Stem Cells
Rats
S Phase

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