Article
Significance of TP53 mutations in human cancer: a critical analysis of mutations at CpG dinucleotides.
Human mutation - 1 Mar 2003
Soussi Thierry, Béroud Christophe
Abstract excerpt
A detailed analysis of p53 (TP53) mutations involving the 42 CpG dinucleotides was performed to gain greater insight into the mutational mechanism leading to specific selection of these mutations. Although the majority of these CpG dinucleotides have been found to be mutated in cancer cells, the heterogeneous frequency of mutational events suggests that some mutations are not true mutations, but neutral changes...
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