Article
5-Methylcytosine as an endogenous mutagen in the p53 tumor suppressor gene.
Princess Takamatsu symposia - 1 Jan 1991
Rideout W M, Coetzee G A, Olumi A F, Spruck C H, Jones P A
Abstract excerpt
Approximately 4% of cytosine residues in human DNA are modified post-synthetically into 5-methylcytosine (5mC) which is the only modified base present in vertebrate DNA. The function of 5mC is not fully understood, but methylation of promoter regions is often associated with transcriptional inactivity and may be part of a gene silencing mechanism. While undermethylation of promoter regions is correlated with...
Topics
- 5-Methylcytosine
- Animals
- Cytosine
- DNA
- Genes, p53
- Humans
- Mutagens
- Mutation
- Neoplasms