Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of the wild-type p53 antioncogene induces guanine nucleotide-dependent stem cell division kinetics.

3 Jan 1995

Abstract excerpt

The predominant type of cell division in adult mammals is renewal growth. Renewing stem cells in somatic tissues undergo continuous asymmetric divisions. One new daughter cell retains the division potential of the original stem cell, while the other differentiates into a functional constituent of the tissue. Disruptions of this process lead to the development of human cancers. We show that through a guanine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer-related Molecular Pathways
Share to Cancer Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7816803
DOI: 10.1073/pnas.92.1.136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of the wild-type p53 antioncogene induces guanine nucleotide-dependent stem cell division kinetics.PMID 7816803Read ↗

The Role of the p53 Protein in Stem-Cell Biology and Epigenetic Regulation.Semantic proximity Read ↗

The Stem Cell Division Theory of CancerSemantic proximity Read ↗

Cancer Stemness: p53 at the WheelSemantic proximity Read ↗

The stem cell division theory of cancer.Semantic proximity Read ↗

Oncogenic Mutant p53 Gain of Function Nourishes the Vicious Cycle of Tumor Development and Cancer Stem-Cell Formation.Semantic proximity Read ↗

The protective role of symmetric stem cell division on the accumulation of heritable damage.Semantic proximity Read ↗

A Distinctive DNA Damage Response in Human Hematopoietic Stem Cells Reveals an Apoptosis-Independent Role for p53 in Self-RenewalSemantic proximity Read ↗

p53 activity is selectively licensed in the Drosophila stem cell compartmentSemantic proximity Read ↗

Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisionsSemantic proximity Read ↗

A new role for p53 in maintaining genetic stability in embryonic stem cells.Semantic proximity Read ↗

Effect of stem cell turnover rates on protection against cancer and aging.Semantic proximity Read ↗

Cellular Senescence: Ex Vivo p53‐Dependent Asymmetric Cell KineticsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.