Article
Complete and tissue-independent methylation of CpG sites in the p53 gene: implications for mutations in human cancers.
Oncogene - 20 Apr 1995
Tornaletti S, Pfeifer G P
Abstract excerpt
CpG dinucleotides are the target of about one third of transition mutations found in human genetic diseases and tumors. Methylation at these sites is thought to be the cause of these genetic changes through spontaneous deamination of 5-methylcytosine. In order to define the contribution of 5-methylcytosine to the spectrum of p53 mutations in human cancers, we have determined the complete DNA methylation pattern...
Topics
- Base Sequence
- Codon
- Genes, p53
- Humans
- Methylation
- Molecular Sequence Data
- Mutation
- Neoplasms
- Oligonucleotides
- Organ Specificity
- Polymerase Chain Reaction