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Article

Elevated mitogen-activated protein kinase activity in estrogen-nonresponsive human breast cancer cells.

Cancer research - 15 Sept 1998

Coutts A S, Murphy L C

Abstract excerpt

The mitogen-activated protein kinase (MAPK) signal transduction pathway plays an essential role in cell cycle progression and can be activated by many growth factor/mitogen pathways including estrogen. MAPK has also been implicated in ligand-independent activation of estrogen receptor-alpha (ER-alpha). The development of estrogen-independent growth in breast cancer is likely a first step in progression to hormone...

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Identifiers

PMID: 9751612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Elevated mitogen-activated protein kinase activity in estrogen-nonresponsive human breast cancer cells.PMID 9751612Read ↗

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