Elevated mitogen-activated protein kinase activity in estrogen-nonresponsive human breast cancer cells.

Article

Elevated mitogen-activated protein kinase activity in estrogen-nonresponsive human breast cancer cells.

Cancer research - 15 Sept 1998

Coutts A S, Murphy L C

Abstract excerpt

The mitogen-activated protein kinase (MAPK) signal transduction pathway plays an essential role in cell cycle progression and can be activated by many growth factor/mitogen pathways including estrogen. MAPK has also been implicated in ligand-independent activation of estrogen receptor-alpha (ER-a...

Topics

Breast Neoplasms
Calcium-Calmodulin-Dependent Protein Kinases
Estradiol
Estrogen Antagonists
Female
Humans
Neoplasm Proteins
Phenotype
Phosphorylation
Polyunsaturated Alkamides
Receptors, Estrogen
Tumor Cells, Cultured

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