Article
Identification of an estrogen-inducible phosphatase (PP5) that converts MCF-7 human breast carcinoma cells into an estrogen-independent phenotype when expressed constitutively.
The Journal of biological chemistry - 20 Jul 2001
Urban G, Golden T, Aragon I V, Scammell J G, Dean N M, Honkanen R E
Abstract excerpt
The proliferation of many estrogen receptor (ER)-positive breast cancer cells depends on estradiol, and tumors arising from these cells are often responsive initially to treatment with selective ER modulators, which produce an antiestrogen effect. However, tumors that are refractory to the antiestrogenic effects of selective ER modulators often reemerge, and the prognosis for these patients is poor because of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.