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Article

Reversal of the estrogen receptor negative phenotype in breast cancer and restoration of antiestrogen response.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2007

Bayliss Jill, Hilger Amy, Vishnu Prakash, Diehl Kathleen, El-Ashry Dorraya

Abstract excerpt

PURPOSE: In breast cancer, the presence of estrogen receptor alpha (ER) denotes a better prognosis and response to antiestrogen therapy. Lack of ERalpha correlates with overexpression of epidermal growth factor receptor or c-erbB-2. We have shown that hyperactivation of mitogen-activated protein kinase (MAPK) directly represses ERalpha expression in a reversible manner. In this study, we determine if inhibition...

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Identifiers

PMID: 18056179
DOI: 10.1158/1078-0432.CCR-07-0587

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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