Article
Characterization of ligand-dependent phosphorylation of the estrogen receptor.
Molecular endocrinology (Baltimore, Md.) - 1 Feb 1994
Lahooti H, White R, Danielian P S, Parker M G
Abstract excerpt
The mouse estrogen receptor is phosphorylated upon estrogen binding at multiple serine residues located mainly between residues 121 and 599. Phosphorylation is progressively reduced in mutant receptors that are defective in estrogen- and DNA-binding activities, suggesting that it occurs in stages, initially as a consequence of hormone binding and subsequently after DNA binding. Phosphopeptide maps of the receptor...
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