Article
Estrogen activates raf-1 kinase and induces expression of Egr-1 in MCF-7 breast cancer cells.
Molecular and cellular biochemistry - 1 Dec 1998
Pratt M A, Satkunaratnam A, Novosad D M
Abstract excerpt
We have investigated whether the raf-1 kinase, a downstream mediator of both receptor tyrosine kinase and protein kinase C signalling, is activated by estrogen (E2) in an estrogen receptor positive human breast cancer cell line. Autophosphorylation of raf-1 kinase was studied after treatment of M...
Topics
- Blotting, Northern
- Blotting, Western
- Breast Neoplasms
- DNA-Binding Proteins
- Early Growth Response Protein 1
- Estradiol
- Female
- Gene Expression Regulation
- Humans
- Immediate-Early Proteins
- Mutation
- Oncogene Proteins v-raf
- Phosphorylation
- Precipitin Tests
- Proto-Oncogene Proteins c-raf
- Receptors, Estrogen
- Retroviridae Proteins, Oncogenic
- Transcription Factors