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Article

Estrogen activates raf-1 kinase and induces expression of Egr-1 in MCF-7 breast cancer cells.

Molecular and cellular biochemistry - 1 Dec 1998

Pratt M A, Satkunaratnam A, Novosad D M

Abstract excerpt

We have investigated whether the raf-1 kinase, a downstream mediator of both receptor tyrosine kinase and protein kinase C signalling, is activated by estrogen (E2) in an estrogen receptor positive human breast cancer cell line. Autophosphorylation of raf-1 kinase was studied after treatment of MCF-7 cells with E2. E2-deprived cells contained low levels of raf-1 kinase activity. Treatment of cells for 1 min with...

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Identifiers

PMID: 9879662
DOI: 10.1023/a:1006827015320

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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