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Article

ERK/MAPK regulation of the androgen responsiveness of breast cancer cells.

Advances in experimental medicine and biology - 1 Jan 2008

Azzam Diana G, Tay Jasmine W T, Greeve Melissa A, Harvey Jennet M, Bentel Jacqueline M

Abstract excerpt

The androgen receptor (AR) is the most widely expressed steroid hormone receptor in human breast cancers and androgens including 5alpha-dihydrotestosterone are potent inhibitors of breast cancer cell proliferation. The extracellular signal-regulated mitogen activated protein kinase (ERK/MAPK) pathway is hyperactivated in a proportion of breast tumors and can interact with steroid hormone receptor signaling by...

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PMID: 18497066
DOI: 10.1007/978-0-387-69080-3_41

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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