Genetic association of two chromosome 14 genes (presenilin 1 and alpha 1-antichymotrypsin) with Alzheimer's disease.

doi:10.1002/ana.410440316

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Article

Genetic association of two chromosome 14 genes (presenilin 1 and alpha 1-antichymotrypsin) with Alzheimer's disease.

Annals of neurology - 1 Sept 1998

Wang X, DeKosky S T, Wisniewski S, Aston, Kamboh M I

Abstract excerpt

We have investigated the association of two candidate genes on chromosome 14, presenilin 1 (PS1) and alpha1-antichymotrypsin (ACT), with the risk of sporadic Alzheimer's disease (AD) by using 427 AD cases and 250 controls. The frequency of the ACT*A allele was significantly higher in cases than c...

Topics

Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Chromosomes, Human, Pair 14
Disease Susceptibility
Female
Genetic Linkage
Genotype
Humans
Male
Membrane Proteins
Presenilin-1
alpha 1-Antichymotrypsin

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