APOE*4-associated Alzheimer's disease risk is modified by alpha 1-antichymotrypsin polymorphism.

doi:10.1038/ng0895-486

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Article

APOE*4-associated Alzheimer's disease risk is modified by alpha 1-antichymotrypsin polymorphism.

Nature genetics - 1 Aug 1995

Kamboh M I, Sanghera D K, Ferrell R E, DeKosky S T

Abstract excerpt

Genetic studies on Alzheimer's disease (AD), a devastating neurodegenerative disorder, have identified the apolipoprotein E (APOE) gene as a strong susceptibility marker for AD. The E*4 allele of APOE is a major risk factor for AD regardless of age of onset or family history. However, the observa...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Apolipoproteins E
Base Sequence
DNA Primers
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Molecular Sequence Data
Polymorphism, Genetic
Risk Factors

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