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Article

APOE*4-associated Alzheimer's disease risk is modified by alpha 1-antichymotrypsin polymorphism.

Nature genetics - 1 Aug 1995

Kamboh M I, Sanghera D K, Ferrell R E, DeKosky S T

Abstract excerpt

Genetic studies on Alzheimer's disease (AD), a devastating neurodegenerative disorder, have identified the apolipoprotein E (APOE) gene as a strong susceptibility marker for AD. The E*4 allele of APOE is a major risk factor for AD regardless of age of onset or family history. However, the observation that the APOE*4 allele is neither necessary nor sufficient for the expression of AD emphasizes the involvement of...

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Identifiers

PMID: 7670501
DOI: 10.1038/ng0895-486

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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APOE*4-associated Alzheimer's disease risk is modified by alpha 1-antichymotrypsin polymorphism.PMID 7670501Read ↗

Polygenic determinants of Alzheimer's disease: modulation of the risk by alpha-1-antichymotrypsin.Semantic proximity Read ↗

A new promoter polymorphism in the alpha-1-antichymotrypsin gene is a disease modifier of Alzheimer's disease.Semantic proximity Read ↗

alpha-1-Antichymotrypsin polymorphism in the gene promoter region affects survival and synapsis loss in Alzheimer's disease.Semantic proximity Read ↗

Alpha-1-antichymotrypsin (ACT or SERPINA3) polymorphism may affect age-at-onset and disease duration of Alzheimer's disease.Semantic proximity Read ↗

No interaction between the APOE and the alpha-1-antichymotrypsin genes on risk for Alzheimer's disease.Semantic proximity Read ↗

Apolipoprotein E and alpha-1-antichymotrypsin allele polymorphism in sporadic and familial Alzheimer's disease.Semantic proximity Read ↗

Genetic variation in alpha(1)-antichymotrypsin and its association with Alzheimer's disease.Semantic proximity Read ↗

Alpha-1-antichymotrypsin gene polymorphism and risk for sporadic Alzheimer's disease in a German population.Semantic proximity Read ↗

Apolipoprotein E and alpha1-antichymotrypsin polymorphism in Alzheimer's disease.Semantic proximity Read ↗

Implication of alpha1-antichymotrypsin polymorphism in familial Alzheimer's disease.Semantic proximity Read ↗

[ACT/AA polymorphism could duplicate the APOE*epsilon4-associated Alzheimer's disease risk].Semantic proximity Read ↗

No association between alpha-1-antichymotrypsin polymorphism and Alzheimer's disease in Chinese.Semantic proximity Read ↗

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