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Article

Polymorphisms in the presenilin 1 and presenilin 2 genes and risk for sporadic Alzheimer's disease.

Journal of the neurological sciences - 15 Dec 1999

Combarros O, Alvarez-Arcaya A, Oterino A, Berciano J, Delgado-Rodríguez M, Peña N, Fernández-Viadero C, Luis Pérez-López J, Setién S, Carvajal A

Abstract excerpt

We examined the possible involvement of polymorphisms of the presenilin 1 (PS1) and presenilin 2 (PS2) genes in the risk for sporadic Alzheimer's disease (AD), either through an independent effect or through interaction with the existing apolipoprotein E (ApoE) risk, in 211 AD cases and 188 age-matched control subjects. No significant differences were obtained in any of the comparisons relating the effect of the...

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Source

Identifiers

PMID: 10581373
DOI: 10.1016/s0022-510x(99)00254-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polymorphisms in the presenilin 1 and presenilin 2 genes and risk for sporadic Alzheimer's disease.PMID 10581373Read ↗

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Presenilin-2 polymorphisms and risk of sporadic AD: evidence from a meta-analysis.Semantic proximity Read ↗

No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a German population.Semantic proximity Read ↗

Presenilin 1 polymorphism associated with Alzheimer's disease in apolipoprotein E4 carriers.Semantic proximity Read ↗

Two polymorphisms of presenilin-2 gene (PSEN2) 5' regulatory region are not associated with Alzheimer's disease (AD) in the Polish population.Semantic proximity Read ↗

Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease.Semantic proximity Read ↗

Presenilin 1 intronic polymorphism is not associated with Alzheimer type neuropathological changes or sporadic Alzheimer's disease.Semantic proximity Read ↗

The Glu318Gly mutation of the presenilin-1 gene does not necessarily cause Alzheimer's disease.Semantic proximity Read ↗

No association or linkage between an intronic polymorphism of presenilin-1 and sporadic or late-onset familial Alzheimer disease.Semantic proximity Read ↗

No association between presenilin 1 (PS1) intronic polymorphism and sporadic Alzheimer's disease in Koreans.Semantic proximity Read ↗

Polymorphism of the regulatory region of the presenilin-2 gene in sporadic Alzheimer's disease: a case-control study.Semantic proximity Read ↗

Presenilin-2 mutation and polymorphism in Japanese Alzheimer disease patients.Semantic proximity Read ↗

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