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Article

Alpha-1-antichymotrypsin (ACT or SERPINA3) polymorphism may affect age-at-onset and disease duration of Alzheimer's disease.

Neurobiology of aging - 1 Oct 2006

Kamboh M Ilyas, Minster Ryan L, Kenney Margaret, Ozturk Ayla, Desai Purnima P, Kammerer Candace M, DeKosky Steven T

Abstract excerpt

In addition to genetic effects on disease risk, age-at-onset (AAO) of Alzheimer's disease (AD) is also genetically controlled. Using AAO as a covariate, a linkage signal for AD has been detected on chromosome 14q32 near the alpha1-antichymotrypsin (ACT) gene. Previously, a signal peptide polymorphism (codon -17A>T) in the ACT gene has been suggested to affect AD risk, but with inconsistent findings. Given that a...

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Identifiers

PMID: 16137793
DOI: 10.1016/j.neurobiolaging.2005.07.015
PMCID: PMC1609963

Genes

APOE
SERPINA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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